Evidence for delayed-type hypersensitivity mechanisms in glomerular crescent formation

Mechanisms of glomerular crescent formation

INTRODUCTION — The presence of crescents in glomeruli is a histologic marker of severe injury. In general, the severity of the renal failure and other clinical manifestations of glomerulonephritis (eg, hypertension, edema) correlates with the percentage of glomeruli that exhibit crescents [1-5]. In addition, the duration and potential reversibility of the underlying disease correspond with the ...

Oral tolerance for delayed type hypersensitivity contribution of local and peripheral mechanisms

Oral tolerance is a physiological immune mechanism, which controls the outcome of deleterious hypersensitivity reactions to environmental antigens absorbed through the gastrointestinal tract, and maintains homeostasis. Using a mouse model of oral tolerance of delayed type hypersensitivity to contact allergens, i.e. haptens, we have examined the mechanisms involved in the induction of oral toler...

THE EFFECT OF ASCORBIC ACID ON BLOOD HISTAMINE LEVEL AND DELAYED-TYPE HYPERSENSITIVITY IN GUINEA PIGS

The effect of ascorbic acid on blood histamine level and delayed-type hypersensitivity was studied in thirty male guinea pigs. Animals were sensitized to B.C.G., trichophytin and mallein during the first four weeks. The diet was ad libitum during this period. After this "sensitization period" animals w er e tested intradermally with tuberculin, trichophytin and mallein. The number and diam...

Hypersensitivity Responses in Cardiac Donor-Reactive Delayed-Type That Plasminogen Activator Controls Mechanisms of Graft Acceptance: Evidence

Hypersensitivity The Role for Decorin in Delayed-Type